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|American Society for Action on Pain|
UI - 000027
AU - Larson AA
TI - Desensitization to intrathecal substance P in mice: Possible involvement of opioids
AB - IN: U Minnesota, St Paul, US LA: English AB: Intrathecal injection of substance P (SP) in mice
resulted in a behavioral syndrome characterized by caudally directed biting and scratching. Repeated
injections of SP resulted in development of tachyphylaxis (TP) to this SP-induced behavioral phenomenon.
Naloxone combined with SP blocked TP to SP in naive Ss. Fluoxetine or phentolamine blocked TP to SP.
(PsycLIT Database Copyright 1989 American Psychological Assn, all rights reserved) KP: chronic pain;
caudally directed biting & scratching induced by intrathecal substance P with vs without naloxone vs
fluoxetine vs phentolamine; mice AN: 76-04403
SO - Pain 1988;32:367-374