Factors Influencing Psychopharmacological Effect

INTERACTION WITH OTHER DRUGS

Little experimental work has been done on the interaction between marihuana and other drugs used socially or medically although this will become an important area as usage increases.

Marihuana is often used with sweet wines to enhance its effect. Some evidence for an additive effect of marihuana and alcohol on motor and mental performance and subjective effect has been seen experimentally (Manno et al., 1971; Jones and Stone, 1970). Some degree of additive effects would be expected with barbiturates based on their similarity to alcohol. A more complex, mixed pattern of effect might be expected with amphetamines and hallucinogens. These latter combinations are rarely used socially (Hollister, 1971).