UI - 000027

AU - Larson AA

TI - Desensitization to intrathecal substance P in mice: Possible involvement of opioids

AB - IN: U Minnesota, St Paul, US LA: English AB: Intrathecal injection of substance P (SP) in mice

resulted in a behavioral syndrome characterized by caudally directed biting and scratching. Repeated

injections of SP resulted in development of tachyphylaxis (TP) to this SP-induced behavioral phenomenon.

Naloxone combined with SP blocked TP to SP in naive Ss. Fluoxetine or phentolamine blocked TP to SP.

(PsycLIT Database Copyright 1989 American Psychological Assn, all rights reserved) KP: chronic pain;

caudally directed biting & scratching induced by intrathecal substance P with vs without naloxone vs

fluoxetine vs phentolamine; mice AN: 76-04403

SO - Pain 1988;32:367-374