UI - 000047

AU - Przewlocki R

AU - Lason W

AU - Silberring J

AU - Herz A

AU - Przewlocka B

TI - Release of opioid peptides from the spinal cord of rats subjected to chronic pain

AB - Chronic localized pain increased the level of the opioid peptides, dynorphin (DYN), alpha-

neoendorphin (ANEO), Met-enkephalin (MET) and Mets-enkephalin-Arg6-Gly7-Leu8 (MEAGL), in the

lumbar enlargement of the rat spinal cord. It was accompanied with a reduction of the spontaneous and K+-

stimulated release of ANEO and MEAGL from spinal cord slices in vitro and a decreased release of ANEO

from the spinal cord in vivo. The results indicate that the reduction in the activity of endogenous opioid

peptide systems might occur in the spinal cord of rats subjected to chronic pain

SO - NIDA Research Monograph Series 1986;75:422-425