UI - 000154

AU - Wilder-Smith CH

TI - [Non-opioids in pain therapy: current perspectives]. [German]

AB - Increasing knowledge of the mechanisms underlying nociceptive processing are making a more

rationale approach to pain treatment possible. Recent research has confirmed relevant differences between

NSAIDs and the direct analgesic action of several psychotropic drugs. Alpha 2-adrenergic agonists are being

clinically tested and have shown considerable analgesic activity in various pain states. Simultaneous

treatment of pain with complementary analgesics, i.e. "balanced analgesia", seems to be a logical approach in

the light of the close interactions between the different nociceptive pathways. The indications for the use of

known analgesics in chronic pain therapy are insufficiently researched.

SO - Schweizerische Rundschau fur Medizin Praxis 1993;82:271-27