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American Society for Action on Pain |
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UI - 000003 AU - Cohen MR AU - Pickar D AU - Dubois M TI - The role of the endogenous opioid system in the human stress response AB - IN: NIMH Clinical Neuroscience Branch, Section on Clinical Studies, Bethesda, MD LA: English AB: Reviews the utilized strategies and the status of experimental work on the involvement of the endogenous opioid system (EOS) in human adaptation to stressors. Three principal research strategies have been used: (1) measurement of endorphin levels in body fluids (CSF and plasma) in relationship to the stress response and the evaluation of effects on the stress response, (2) enhancement of the functioning of the EOS by administering an opioid agonist, and (3) suppression of the functioning of the EOS by the administration of an opioid antagonist (principally naloxone). Clinical studies with humans have demonstrated some stress- induced analgesia, increased plasma levels of beta-endorphin after demanding physical exercise and in later stages of labor, and decreases in lumbar CSF opioid levels in Ss suffering from chronic pain. In surgical studies, evidence was found that elevated plasma beta-endorphin levels may be considered a biologic marker of the human stress response. In addition, alterations in the physiological response to surgical stress followed administration of opiates, suggesting the potential of the EOS to modify stress responses. (75 ref) (PsycLIT Database Copyright 1984 American Psychological Assn, all rights reserved) KP: endogenous opioids; stress responses; humans; literature review AN: 71-28038 SO - Psychiatric Clinics of North America 1983;6:457-471 |