UI - 000013

AU - Akil H

AU - Watson SJ

AU - Sullivan S

AU - Barchas JD

TI - Enkephalin-like material in normal human CSF: Measurement and levels

AB - IN: Stanford U School of Medicine, Nancy Pritzker Lab of Behavioral Neurochemistry LA: English

AB: Identified an opioid substance in lumbar cerebrospinal fluid (CSF) that appears to resemble methionine-

enkephalin in its behavior in 2 chromatographic systems. Ss were 10 normal 19-28 yr old males and 5 Ss

with chronic intractable pain who were undergoing a neurosurgical procedure for the alleviation of that pain.

The substance appears to interact with the opiate receptor assay and with a methionine-enkephalin

radioimmunoassay. While this material resembles enkephalin, it could not be identified as such with the

techniques employed in the present study. (9 ref) (PsycLIT Database Copyright 1979 American

Psychological Assn, all rights reserved) KP: identification & measurement of enkephalin-like material in

cerebrospinal fluid; 19-28 yr old males & Ss with chronic pain AN: 62-13062

SO - Life Sciences 1978;23:121-125