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American Society for Action on Pain |
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UI - 000237 AU - Tennant FS Jr. AU - Tate JA AU - Ruckel E TI - Clinical trial in post-addicts with oxilorphan (levo-BC-2605): a new narcotic antagonist AB - AB - Oxilorphan (levo-BC-2605) is a new, long-acting, narcotic antagonist that has agonist properties. Twenty-one (21) heroin addicts in Los Angeles were detoxified and given at least one oral dose of oxilorphan. Only three (14.3%) patients took daily doses for 14 days, which was the maximal time allowed for oxilorphan administration in this study. The remainder discontinued oxilorphan because of subjective side effects or for unknown reasons. Side effects most responsible for dropouts were dysphoria, insomnia, weakness, hallucinations, nausea, drowsiness and anorexia. Oxilorphan provided 24-hour protection with a single, oral dose, but subjective side effects encountered during inductiolinical trials with oxilorphan should be attempted with other addict populations to fully determine its potential therapeutic value UI - 77115504 SO - Drug Alcohol Depend 1976;1:329-337 |