UI - 000156

AU - Osipova NA

AU - Petrova VV

AU - Novikov GA

AU - Beresnev VA

AU - Sergeeva IE

AU - Dolgopolova TV

TI - [Norfin in oncological practice]. [Russian]

AB - A synthetic opiate agonist-antagonist norphin (buprenorphin) has been studied in 297 cancer patients

as an analgetic component of general anesthesia, in postoperative analgesia and in the treatment of chronic

pain syndrome. In modified neuroleptanalgesia based on norphin, diazepam, droperidol and N2O the patient

is more adequately prevented from surgical trauma than in conventional neuroleptanalgesia based on

fentanyl. This is confirmed by greater stability in circulation, metabolism and stress

hormone parameters, however this anesthesia technique is less manageable and may be accompanied by

prolonged postanesthesia depression of the central nervous system. Good results have been obtained when

norphin pills were used sublingually for the treatment of long-lasting intensive chronic pain syndrome in

incurable cancer patients. Norphin is no less effective than morphin, however, unlike morphin, it causes no

severe adverse reactions.

SO - Anesteziologiya i Reanimatologiya 1992;:3-