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Drugs Which May Lower Plasma Levels of Methadone or Decrease Methadone Effects
| Generic Name |
Action/Use |
Brands/Examples |
| Butabarbital sodium, mephobarbital, phenobarbital, pentobarbital, secobarbital |
barbiturate sedatives and/or hypnotics |
Bitosol Sodium, Mebaral, Nembutal, Phenobarbital, Seconal |
| carbamazepine |
anticonvulsant for epilepsy and trigeminal neuralgia |
Atretol, Tegretol |
| ethanol |
chronic use |
wine, beer, whiskey, etc. |
| phenytoin |
control of seizures |
Dilantin |
| rifampin |
Treatment of pulmonary tuberculosis |
Rifadin, Rifamate, Rifater, Rimactane |
| urinary acidifiers, ascorbic acid |
keeps calcium soluble, controls urine-induced skin irritations, vitamin C |
K-Phos, Vitamin C (large doses) |
Drugs Which May Increase Plasma Levels of Methadone or Increase Methadone Effects
| Generic Name |
Action/Use |
Brands/Examples |
| amitriptyline |
treatment of depression and anxiety |
Elavil, Endep, Entrafon, Limbitrol, Triavil |
| cimetidine |
H2 receptor antagonist for the treatment of gastric and duodenal ulcers, and gastric reflux disease |
Tagamet |
| diazepam |
control of anxiety and stress |
Dizac Vairelease, Valium |
| ethanol |
acute use |
wine, beer, whiskey, etc. |
| fluvoxamine maleate |
serotonin reuptake inhibitor for treatment of depression and compulsive disorders |
Luvox |
| ketoconazole |
anti-fungal agent |
Nizoral Tablets |
| urinary alkalinizers |
treatment of kidney stones, gout therapy |
Bicitra, Polycitra |
Charts from A.T. Forum, (1997, Spring). Vol. VI, #2, p. 3.
Some drugs that cause false positives
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