The National Commission on Marihuana and Drug Abuse
Marihuana - A Signal of Misunderstanding.
Chapter II
marihuana use and its effects
Method of Use
The method of use has a bearing upon the drug effect. The method is directly related to
both dosage and time lapse before the drug effect is felt. Injection directly into a vein
delivers the total dose immediately, producing a rapid, maximal response of minimal
duration. Smoking and inhalation cause rapid but less efficient delivery of the dose;
variable quantity of the drug is destroyed during burning or escapes into the air and does
not reach the lungs. Oral ingestion produces different effects, according to the system in
which the drug is dispersed. Generally, oral ingestion diminishes the drug effect, but
prolongs it.
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