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Authors 
Martellotta MC. Cossu G. Fattore L. Gessa GL. Fratta W.

Institution 
Bernard B. Brodie Department of Neuroscience, University of Cagliari, Italy.

Title 
Self-administration of the cannabinoid receptor agonist WIN 55,212-2 in drug-naive mice.

Source 
Neuroscience. 85(2):327-30, 1998 Jul.

Local Messages 
HSCL owns

Abstract 
Marijuana is one of the most widely used illicit recreational drugs. However, contrary to the majority of drugs abused by humans, there is a general opinion that rewarding effects are not manifested by animals. We studied a synthetic cannabinoid agonist WIN 55,212-2 using an intravenous self-administration model in drug-naive mice. The results of this study show that WIN 55,212-2 was intravenously self-administered by mice in a concentration-dependent manner according to a bell-shaped curve. Thus, self-administration of WIN 55,212-2 significantly increased, with respect to the vehicle self-administration control group, at concentrations of 0.5 and 0.1 mg/kg per injection. However, at WIN 55,212-2 concentration of 0.5 mg/kg per injection, self-administration significantly decreased. The results obtained show how WIN 55,212-2 is able to elicit both rewarding and aversive effects depending on the concentration used. Pretreatment of mice with the cannabinoid CB1 receptor antagonist SR 141716A (0.25 mg/kg, i.p.) completely prevented WIN 55,212-2 (0.1 mg/kg per injection) self-administration, indicating that WIN 55,212-2 rewarding effects are specifically mediated by cannabinoid CB1 receptors.

martellotta-01.pdf
file size: 572.14KB (585872 bytes)