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Conference Reports
International Cannabinoid Research Society
1998 Symposium on Cannabinoids
The annual meeting
of this group of research scientists was held in La Grande Motte, France during
July 23-25, 1998, for the first time outside of North America. The conference
was attended by about 150 scientists -- largely from academic laboratories in
Europe and the US. A total of 135 papers was presented, but only a few personal
highlights will be described here.
A substantial number of papers
focused on the naturally occurring cannabinoids in brain and in peripheral
tissues. At least two lipid derivatives are now recognized: anandamide
(arachidony ethanol-amide) and an arachidonic acid ester, 2-arachidonyl glycerol
(2-AG). The latter substance is as potent as anandamide and is present in larger
quantities than anandamide in the brain. Several papers focused on the
biochemical mechanisms involved in the synthesis and degradation of these lipids
in brain tissue, and progress has been made in defining the biochemical
mechanisms involved. Attention has also focused on the development of
metabolically more stable chemical analogs of anandamide and 2-AG with improved
activity in whole animal studies. The naturally occur-ring compounds are rapidly
degraded and are thus not very active in vivo. Another lipid, palmitoyl
ethanol-amide, may represent the natural activator of CB2 receptors, although
there was some disagreement about its pharmacological activity and selectivity.
Whether the endogenous cannabinoids
will form the basis for useful new medicines remains unclear, although David
Pate (HortaPharm B.V., The Netherlands) and colleagues (Univ. of Kuopio,
Finland) described promising results for the reduction of intraocular pressure
when a metabolically stable anandamide analog was applied topically to the
normal rabbit eye. This effect appeared to involve a local CB1 receptor
mechanism, as it could be blocked by subcutaneously pretreating the animals with
the CB1 receptor specific antagonist SR141716A. In order to deliver the
water-insoluble anandamide analog to the eye, it was first dispersed in an
aqueous solution containing a beta-cyclodextrin carrier.
Several groups are studying the
detailed molecular architecture of the CB1 and CB2 receptors and beginning to
identify the precise sites at which the cannabinoids bind to these proteins.
Studies of the receptors using in vitro model systems have revealed some
interesting differences between the effectiveness of various cannabinoids in
activating the receptors. In particular, Δ9-THC
appears to act as only a partial agonist at the CB1 receptor (i.e. it
cannot elicit a maximum response). Cannabidiol - one of the most abundant Cannabis
compounds - on the other hand, appears to act as an antagonist at the CB1
receptor.
The CB1-selective antagonist drug
SR141716A and the related CB2-selective antagonist SR144528, both from the
French pharmaceutical company Sanofi, were the subject of many papers, and these
compounds have proved to be important new research tools for probing cannabinoid
functions. Scientists from Sanofi revealed that they are developing SR141716A
for clinical trials, with schizophrenia as their first target, based on their
rationale that high doses of THC can cause a schizophrenia-like psychosis in
some people. A novel CB1 antagonist CP-272871 from Pfizer was also described,
for the first time, and has properties similar to those of SR141716A.
The CB2 receptor, located principally
on cells in the immune system, has attracted attention from a number of major
pharmaceutical companies as a potential target for discovering novel
anti-inflammatory or immunosupressant drugs. There has been good progress in
identifying CB2-selective drugs (e.g., from Merck Frosst, Glaxo-Wellcome,
Smith Kline Beecham), but so far, there is little confidence that this target
will prove useful. Dr. Nancy Buckley (US National Institutes of Health)
described the "CB2 knockout mouse" in which, as a result of genetic
engineering, the CB2 receptor is no longer expressed. These mice, how-ever,
seemed remarkably normal in their immune cell population and in immune function
and have not, so far, greatly assisted understanding the role normally played by
the CB2 receptors.
The possible adverse effects of long
term Cannabis use were described by Donald Tashkin and colleagues (UCLA)
who reported that treatment of mice with THC (5 mg/kg four times a week) led to
more rapid growth of implanted lung cancer cells and decreased survival. It was
suggested that THC may suppress immune-mediated eradication of tumor cells.
A special session sponsored by the US
National Institute on Drug Abuse focused on the effects of long term Cannabis
use on frontal lobe function in man. A series of studies using imaging, cerebral
blood flow and EEG measurements indicated depressed frontal lobe function in
long term Cannabis users, and there were accompanying subtle deficits in
sensory and cognitive processing - in the so called "executive
functions" of the brain. There was little evidence, however, that any of
these effects persisted after cessation of drug intake.
Billy Martin et al. (Medical
College of Virginia, USA) described an animal model of Cannabis
dependence. When dogs were treated with high doses of THC for 7-14 days and then
challenged with the CB1 antagonist SR141716A, clear physical signs of withdrawal
became apparent - these included trembling, shaking, restlessness, vomiting and
diarrhea. By using the antagonist challenge model it has become much clearer
that physical dependence and withdrawal can occur with large doses of THC, at
least in animals.
Furthermore, Fernando Rodriguez de
Fonseca et al (Madrid) reported that the administration of SR141716A to
morphine-dependent animals elicit-ed a behavioral and endocrine syndrome similar
to that seen in opiate withdrawal, although considerably milder. Conversely some
withdrawal signs could be elicited in cannabinoid dependent animals when
challenged with the opiate receptor antagonist naloxone - suggesting an
interaction between the opioid and cannabinoid systems in brain.
The interaction of opiate and
cannabinoid mechanisms was also high-lighted by Sandra Welch (Medical College of
Virginia, USA) who reported that low doses of THC significantly potentiated the
pain-relieving effects of morphine and other opiates in a mouse model of
arthritis-like pain. Higher doses of THC were also, by themselves, fully
effective in causing analgesia in this model. She is planning a clinical trial
(with the approval of the US Food & Drug Administration) of low doses of THC
(dronabinol) in conjunction with self-administered morphine in patients
suffering from cancer pain, in the hope that the drug combination may make
morphine more effective in such patients.
Further evidence for a possible
utility of cannabinoids in the treatment of pain was reported by Daniele
Piomelli et al. (UC Irvine) who described powerful analgesic effects of
anandamide when injected directly into the rat paw in an inflamed paw model of
inflammatory pain. The mechanism appeared to involve both CB1 and CB2 receptors
located on sensory nerve fibers in the skin, and when a combination of
CB1-selective and CB2-selective compounds was injected, there was synergy
between them. Experiments using radio-labelled anandamide showed that >90% of
the injected dose remained in the paw, and very little entered the brain or
spinal cord. These results are highly original and suggest the possibility that
cannabinoids can exert pain-relieving actions without having to penetrate into
the CNS.
Other medical applications were
suggested by the results of an anonymous survey conducted by P. Consroe (Univ.
of Arizona, USA) and R. Musty (Univ. of Vermont) on 106 patients with spinal
cord injuries who were self-medicating with smoked marijuana. The patients
smoked an average of 4 joints a day, 6 days a week and had been doing so for
>10 years. More than 90% report-ed that Cannabis helped improve
symptoms of muscle spasms of arms or legs, and improved urinary control and
function. Around 70% reported pain relief. The results of this survey and a
similar one conducted earlier by R. Pertwee in MS patients may help to pinpoint
the relevant symptoms to focus on, as outcome measures in future clinical trials
of Cannabis or cannabinoids.
The availability of
"standardised medical grade marijuana" for such clinical trials was
described by J. Khodabaks and O. Engelsma (Mari-pharm, The Netherlands). The
laboratory cultivates standardized Cannabis plants selected for a high
yield of THC and low content of other cannabinoids, these are cloned by
propagating (by cuttings) from female plants. The plants are grown under
standard conditions and the female flower heads harvested and vacuum-sealed for
storage and then gamma-irradiated to sterilize the preparations. Samples are
routinely checked for THC and other cannabinoids and to ensure that they are
free of pesticides. The THC content in different batches was highly consistent
at 10.7% (0.1% standard deviation). Interestingly, in light of discussions about
the relevance of other cannabinoids in herbal Cannabis, cannabidiol and
cannabinol are present in only minor amounts (< 0.1%) in these samples.
Some facts to illuminate discussions
about "super potent" Cannabis were provided by Mahmoud ElSohly
(Univ. of Mississippi) who summarized results obtained from the analysis of
confiscated marijuana samples. This service has been running since 1980 at the
University of Mississippi and involves the analysis of samples from all regions
of the United States. Data from 35,312 samples were available. The potency of
marijuana leaf samples (the commonest in US seizures) rose from around 1.5% THC
content in 1980 to around 3% in the 1980’s and most recently to 3.87% in 1996
and 4.15% in 1997. The THC content of ‘sinsemilla’ (the female plant flower
head) rose from around 6.5% in 1980 to 9.22% (1996) and 11.53% (1997). The
increases are thought to be due to improved culture conditions rather than to
any genetic improvements. Analysis of samples of Cannabis resin or oil
revealed few discernible trends, with figures ranging from 3% to 19% THC
content.
Leslie Iversen
Pharmacology Dept.
Oxford University
Winnipeg’s Hemp Farming & Equipment Show
The Hemp Farming & Equipment Show, held at the Winnipeg
Convention Centre on October 13-14, 1998, was a resounding success. Produced by
Wiseman Noble Sales and Marketing Ltd., the two day event brought together
farmers, international and Canadian hemp experts, and representatives from
government and financiers, in a conference that will help move hemp forward in
Manitoba and across Canada. Based on the results of the show. The Hemp Farming
& Equipment show will become an annual event, and is poised to help ensure
that Manitoba will remain a leader in Canadian hemp production.
The Hemp Farming & Equipment Show
was developed by Wiseman Noble for the Manitoba Hemp Association (MHA), a newly
forming not-for-profit association that is dedicated to the promotion of
"Hemp by and for Manitobans." The MHA is made up of experienced
industrial hemp farmers, researchers, hemp entrepreneurs, retailers and others
interested in seeing the hemp industry develop in Manitoba. After the show, it
was announced that Wiseman Noble will be selling the successful event to the MHA
for the sum of one Canadian dollar.
"The HFES will be sold to the
MHA once it has selected a full board and is incorporated as a non-profit
association," says Sotos Petrides, show producer, and President of Wiseman
Noble. ‘The board will be composed of all parties interested in industrial
hemp initiatives. It is important that everyone in Manitoba shows support for
this new association."
The HFES was the sixth event dealing
with hemp and other alter-native fibers that Wiseman Noble has produced since
the annual Commercial & Industrial Hemp Symposium, first held in Vancouver
in February 1997.
Conference delegates received
valuable information, whether they were preparing to grow hemp on a substantial
scale in 1999 or were only looking to grow the crop for first time. Delegates
and speakers reported on high yields in the first year of growing hemp
commercially, how demanding hemp was on farm machinery, and the various methods
used to harvest this crop across Canada. Delegates were also excited by new
technologies that may be useful in processing hemp. While there is clearly no
shortage of interest by farmers wanting to grow the crop, speakers also advised
on the need for market development, which is required to move the industry
forward.
The trade show brought together
community and rural development organizations, Manitoba agronomists, and
exhibitors displayed cutting edge technology and science that will be useful to
anyone interested in this new crop. The trade show also exhibited value-added
products showing the versatility of end uses for hemp. On the evening of the
13th, delegates and the public were treated to an exciting night of hemp
fashions. Designers that were represented included Ashira, Club Kanhai,
Ecolution, Labyrinth, Nomads 1800, Sand-stone, Simply Hemp, Spiral, Spirit
Stream, The Hemp Club and Two Star Dog. Sponsors included The Bank of Montreal,
Manitoba Agriculture and Commercial Hemp magazine.
For more information please visit the
Wiseman Noble web page at www.wisenoble.com
or contact:
Wiseman Noble Vancouver
Ste. 302-505 Hamilton St. 597
Vancouver, BC
V6B 2R1 Canada
Tel: +1 (604) 662-8600
Fax: +1 (604) 662-8621
events@wisenoble.com
Wiseman Noble Winnipeg
Gertrude Ave.
Winnipeg, MB
R3L 0M9 Canada
Tel: +1 (204) 474-0987
Fax: +1 (204) 284-6820
mlangtry@pangea.ca
Mike Langtry
Wiseman Noble
NAIHC Conference
The North American
Industrial Hemp Council (NAIHC) annual business meeting and conference held at
the Crown Plaza Hotel in Washington, D.C., November 5-7, 1998, was an
interesting mix of market development and mounting political pressure. The
conference emphasized the need for developing hemp markets and the success of
Canada’s first commercial plantings. About 30 speakers addressed a packed room
of delegates drawn from across North America and Europe.
Stan Blades of the Alberta Department
of Agriculture gave a balanced overview of the agricultural practices of hemp
farming. Several conference panels focused on the opportunities for processing
and marketing hempseed products. Marjorie McGinnis, of Frederick Brewing
Company, makers of Hempen Ale, shared her challenges of developing and selling
their hemp beer line. Richard Rose of the Hemp Nut Corporation discussed the
many nutritional benefits and food uses of hulled hemp seed. Three major
Canadian hempseed processors, Jean Laprise of Kenex, Greg Herriott of Hempola,
and Ruth Shamai of R & D Hemp explained how their respective companies are
creating markets for their hempseed derivative products. Market penetration was
looking promising as the Canadian contingent outlined their strategies for
capturing market share in the massive US marketplace. R & D hemp is breeding
a high GLA hemp seed strain to capture a share of the lucrative and growing
healthfoods market. Hempola gave an impressive presentation outlining plans to
market their hemp seed derived products of flour, oil and soap. Canadian Senator
Lorna Milne also attended.
English body-care products
entrepreneur, Anita Roddick, founder of The Body Shop, pointed out the almost
laughable hurdles that various government agencies have placed in front of them
as the firm launches their hemp line in Canada, England and France. She provided
yet another potential market by stating that The Body Shop would consider
building new Body Shop stores using hemp if those products were available. On
the fiber side, a variety of presentations were made on the subjects of paper,
building materials, and automotive parts. England’s Stuart Carpenter, formerly
of Hemcore, gave an update on European hemp activities. One of the more
promising aspects of this, was utilizing fiber hemp as a strengthening agent for
making polypropylene products.
The other top issue was the mounting
political pressure for the re-introduction of industrial hemp. The political
situation was covered by representatives David Monson of North Dakota and
Cynthia Theilan of Hawaii. NAIHC board members Jeff Gain, Andy Kerr and Ned
Dailey discussed some of the strategies for legalizing hemp in the United
States, including a NAIHC petition to transfer regulatory authority from the
Drug Enforcement Administration to the Department of Agriculture, as well as
other legal actions. William Holmberg, a former Marine and President of Global
Bio Refineries, provided a plan to increase the political pressure on Government
to legalize industrial hemp.
Over 120 attendees enjoyed a
delicious hemp foods banquet coordinated by Richard Rose of the Hempnut
Corporation. Foods included: pasta with hemp pesto, breaded zucchini sticks with
hemp cheese sprinkled with dehulled hemp seed, a hemp-olive oil salad dressing,
and a chocolate HempNut™ dessert. Rounding out this most successful evening
was Ralph Nader, who addressed the banquet audience and threw his support behind
industrial hemp legalization. He compared the US government’s hemp policy to
the Catholic church’s view that Galileo be imprisoned for saying that the
earth rotates around the sun.
The NAIHC business meeting discussed
the council’s activities including media efforts, market development, and the
full board’s approval to form a sister 501(c)6 trade association.
The final speaker, Joe American Horse
of the Lakota Sioux Nation gave a humble, yet powerful presentation. His tribe
is located in the poorest county in the United States and he sees hemp as a way
to create greater economic opportunities, along with helping to feed, shelter,
and clothe his people.
It may still be a few years before
the United States legalizes hemp. However judging by the interest and calibre of
speakers and attendees at this year’s annual conference, the commercial
cultivation of American industrial hemp is an inevitability.
The next NAIHC conference will be
held in November 1999 in Memphis, Tennessee. For more information contact: North
American Industrial Hemp Council at www.naihc.org
or e-mail to: chair@naihc.org.
Jason Freeman , Wiseman Noble
and John W. Roulac - Hemptech
San Francisco Industrial Hemp Expo ‘98
The "Expos of
the Americas" group recently produced the largest industrial hemp expo to
date on the North American continent at the Festival Pavilion, Fort Mason
Center, San Francisco on November 14-15. The event was designed to address the
needs of the industry, the curiosity of the local community and the concerns of
the general public. On-site preparation started during the early hours on
Friday, November 13th.
Dennis Cicero from the Galaxy Global
Restaurant arrived from New York City and immediately started to prepare the
food for that evening’s candlelight dinner. The meal was a fund-raiser for
Headwaters Redwood Forest, designed to honor Julia Butter-fly Hill. She has been
living atop a redwood tree since December 1997, in protest of Pacific Lumber’s
continued destruction of the Headwaters Forest. Several chefs and some very
capable volunteers assisted. Vendor-setup and registration started at 11:00 AM.
As the hours passed, Fort Mason’s empty shell came alive with the energy of
enthusiastic hemp vendors and educators. The rest rooms were stocked with great
skin care products donated by various hemp vendors. Breathtaking works of art
were placed near the entrance, including the hemp goddess, created by Carrie
Eheler. And the Head- waters Altar, inspired by Dianna Sarto, made a strong
ecological statement.
Set-up ended around 6:30 PM and
tables were prepared for that evening’s benefit dinner. Several hours later, I
passed through the entrance of the venue to find the space had trans-formed into
a classy and stylish restaurant. Tables were draped with hemp tablecloths and
decorated with hemp candles in hemp-beeswax shells. Throughout the evening,
"Friends of Bob" entertained us, with their music. The meal was
prepared with organic food supplied by the Rainbow cooperative grocery in San
Francisco. The menu was filled with hempen tastes, serving fresh spiced pumpkin
soup with HempNut™ crisps, seasonal greens with hemp-pumpkin-citrus
vinaigrette, open-faced Japanese raviolis with wild mushroom and leek ragout,
hemp-balsamic scampi, Hemp-Nut™ baklava with fresh berry coulis and
hempseed caramel. All topped off with hemp coffee after dessert!
During that evening John Howell,
editor of Hemp Times magazine, recognized the winners of the second
annual Hemp Achievement Awards. As a top to the evening, modern cellular phone
technology made it possible for Julia Butterfly Hill to speak to us from the top
of her tree.
A delicious organic hemp pan-cake
breakfast was served the following morning, presented on biodegradable plates
accompanied by cups, forks, spoons, knives and garbage bags provided by Biocorp.
While vendors added the final touches
to their booths, the "wholesale- only" hours arrived and buyers were
admitted through the doors early. During this time, I was pleased to spot buyers
from such large clothing retailers as Macy’s and Nordstrom’s, hunting
products. I saw Woody Harrelson’s hemp tuxedo, made for the 1995 Academy Award
ceremony, being positioned for display. Several members of the San Francisco
Police Department were roaming the booths. They expressed to me a genuine
interest in educating themselves to the developments in the hemp industry.
The Blue Sun Café featured their
vegetarian "Hemp, Hemp, Hooray!" menu where I sampled some delicious
hemp crust pizza. Special presentations included the twice-daily Hemp Times
magazine Hemp Fashion Show, that utilized selected apparel from the exhibit
floor. Publishers of HempWorld, the international trade journal, provided
many great books and educational materials throughout the show. A camera crew
from ABC walked through the venue, filming a piece that aired on national
television the following week. Hemp beer and hemp wine were served on the
mezzanine level, which offered a panoramic view of The Bay. Running parallel
with the exhibits was an extensive speaker program, hosted by the Magic Theatre.
The two-day program served mainly as an educational forum and a meeting of minds
for all participants and attendees. Topics included: Sovereign Rights, Hemp
Food, Paper and Fuel, Fiber, and Organic Growing Techniques, just to name a few.
On the main stage, Pete Brady delivered a powerful and thought-provoking keynote
speech.
Saturday evening, I found myself at
the vendor appreciation party. The festivities were held in a grand old ballroom
located at the International Center in San Francisco. The band Rocksteady played
and a liquid light show was provided by Liquid Light Productions. For the
remainder of the weekend, wholesalers and retailers were provided with an ideal
opportunity to network. It was refreshing to see many different educational
booths and non-profit organizations participating in the Expo.
After breakdown of the show booths
had been completed, I stood in the once again dark and empty hall while vibrant
memories of the positive energy, that had been generated by so many wonderful,
strong and committed individuals, flowed through my mind. I feel fortunate to
have been a participant in, and a witness to, one of the most insightful and
inspirational efforts to further the struggle for hemp acceptance, organized to
date.
The goals of the event were to
publicize, welcome and celebrate the timely return of a thriving domestic hemp
industry; to lay out the enormous potential of the hemp plant as a sustainable
commodity; and to advocate hemp as a fitting industry for the new millennium. I
am of the opinion that it succeeded.
Jerusha Rich
Medical Cannabis congresses in Germany
Three events in
four days. The first week of December 1998 was filled with impressive meetings
and discussions about the medical use of Cannabis with good resonance in
the German media: the congress "Medical Marijuana" from December 2-4
in Frankfurt, the general meeting of the Association for Cannabis as Medicine on
December 4, and the conference "Cannabis and Cannabinoids as Medicine ‘98"
on December 5 in Cologne.
The meeting at the Congress Center of
Frankfurt provided a plat-form for political discussion along with information
about the therapeutic potential of Cannabis and the state of debate in
several countries given by specialists such as Dr. Roger Pertwee from the
University of Aberdeen, Prof. Rudolf Brenneisen from the University of Bern, Dr.
Lester Grinspoon from Harvard University in Boston, Dr. Franjo Grotenhermen from
nova-Institute in Cologne, Dr. Geoffrey Guy from GW Pharmaceuticals in Great
Britain and others. Dr. Christian Rätsch, Prof. Sebastian Scheerer and Prof.
Lorenz Böllinger gave insight into the history of the medical use of the Cannabis
plant, the backgrounds of inter-national drug policies of this century and
actual legal aspects. Journalists were much interested in the remarkable report
of a Swiss patient from the REHAB in Basel/Switzer-land, where a study was
initiated in 1997 with oral and rectal THC for organically caused spasticity,
under the guidance of Dr. Ulrike Hagenbach.
The Frankfurt congress was organized
by the Hessian Society for Democracy and Ecology e.V., Regional Foundation of
the Heinrich Böll Foundation, and by the metropolitan AIDS support centers in
Cologne, Frankfurt/Main, Dusseldorf and Munich. It profited from the good
contacts of the organizers to the media and to important persons from politics,
art and science. Participants in the political debate on the last day of the
meeting were members of the German parliament, Gudrun Schaich-Walch from the
Social Democratic Party, Detlef Parr from the Free Democratic Party and Monika
Konoche from the Greens. Helmut Butke from the German Health Ministry, head of
the department for narcotics, said that the government had no problems with the
therapeutic use of the Cannabis plant. Laws had to be changed if it was
necessary for the well-being of the people. But he pointed out that this could
only happen after an approval of a Cannabis-based medicament. Politicians
from the Social Democrats and the Greens spoke out for a quick procedure to
introduce such a medicament, given that studies had proven its medicinal value.
Rüdiger Kriegel, from the board of Directors of the Deutsche AIDS-Hilfe
(Federal AIDS- support organization of Germany), spoke up for a rapid end of the
inhumane conditions concerning procurement of Cannabis for seriously ill
patients, thereby expressing the wishes of the majority of the Congress’
participants. At the end of the congress, the "Frankfurt Resolution"
was presented. It says:
"We believe that all possible humane medical means ought to be utilized for the cure of the ill and the alleviation of their suffering, and therefore we request the German Parliament: 1. to allow the medical use of marijuana, 2. also to permit the inhalative application of natural marijuana for therapeutic purposes, 3. to scientifically study the medical uses of marijuana and to subsidize this research."
Among the first
signers of the resolution are well-known actors and other artists, journalists
and other persons from the media, university professors and scientists,
politicians from the Social Democrats and the Greens, and the political parties
that have formed the German government since the elections of Autumn 1998. The
resolution is supported by the Association for Cannabis as Medicine, the German
Society for Drug and Addiction Medicine and other medical associations have also
signaled their support. Signatures will be collected and will be handed over to
the German government in March of 1999.
In their general meeting on Friday,
December 4 in Cologne, the Association for Cannabis as Medicine (ACM) demanded
impunity for seriously ill patients who use cannabis for medicinal purposes. It
was unacceptable that patients must endure the judicial consequences of their
self-treatment along with the symptoms of their illnesses. Despite certification
by their physicians and expert opinion about the therapeutic uses of Cannabis,
patients in Germany suffering from epilepsy, AIDS, hepatitis C, spinal cord
injury and poliomyelitis had been convicted of infringement of the Narcotics
Act.
The ACM demands amnesty for these
patients. The convictions contradict the sense of justice of almost all citizens
who have heard about these court proceedings and their circumstances. Judges
repeatedly found themselves in a situation where they had to convict people
according to the letter of the law though they felt much sympathy for their
actions. It was pointed out that the ACM welcomes and supports clinical studies
with THC and Cannabis that are planned or are already underway in Great
Britain, Switzerland and Germany, since they can further improve the knowledge
of the therapeutic qualities of Cannabis and the cannabinoids. But the
available evidence should already be reason enough to allow seriously ill
patients an exception from the general prohibition of Cannabis. Cannabis
pro-ducts brought about less side-effects than many legally available medicines.
The ACM emphasized that legislators
are already in a position to offer impunity to patients in the case of medically
substantiated consumption of Cannabis, if that is what the parliament
wants. Medical approval was by no means compulsory. This has already been
ascertained for Great Britain by the House of Lords that published a report on
November 11 in favor of the legalization of Cannabis for therapeutic
purposes. In Germany, jurists were increasingly considering it
"injustice" that seriously ill patients are denied Cannabis
products. For example, an article in the German law magazine Juristenzeitung
of February 1998, written by Jürgen Schwabe, Professor of Law at Hamburg
University, described the judicial situation as "scandalous". It was
considered at the ACM General Meeting to bring an action to the Federal
Constitutional Court of Germany. The legislative correction of this injustice
should happen as quickly as possible, independent of lengthy processes for the
approval of a Cannabis medicament.
The participants of the meeting
noticed that since the founding of the ACM in April 1997, and since the last
meeting in November 1997, the interest in the medical uses of Cannabis
had increased rapidly in the German speaking countries Germany, Austria and
Switzerland. National contacts to other medical organizations and to
politicians, as well as international contacts had been improved, furthering the
exchange of ideas.
Detailed information about the
current scientific level of knowledge was offered during the conference
"Cannabis and Cannabinoids as Medicine ‘98", organized by the ACM in
cooperation with various other medical societies, the German Society for Drug
and Addiction Medicine, the Society of Pain Therapists (STK), the German Society
for Therapists of the HIV Infected (DAGNE), the German AIDS Support Organization
(DAH) and the German Association for Epilepsy.
Dr. Lester Grinspoon pleaded for the
medical use of marijuana. He did not think that medical use could be treated as
a distinct issue, but that the full potential of Cannabis would only be
realized when the present era of prohibition had ended. Dr. Christian Rätsch
spoke about the ethnopharmacological uses of Cannabis where, in contrast
to the symptom-oriented modern medicine, the psychotropic effects experienced by
the shaman and/or the patient were generally regarded not as side-effects, but
as relevant for the healing effect of the drug.
Prof. Robert Gorter and Dr. Martin
Schnelle presented preliminary results of a standardized patient survey,
conducted in the German-speaking countries, about their experiences with the
medicinal uses of THC and natural Cannabis products. The survey was
brought about by the ACM and the European Institute for Oncological and
Immunological Research in Berlin in April 1998. Dr. Roger Pertwee presented the
current knowledge of the cannabinoid receptor system and discussed consequences
for potential therapeutic applications of cannabinoid receptor ligands and
antagonists. In a second part, he gave an overview of studies and experiences
with cannabinoids in multiple sclerosis and spinal cord injury.
Prof. Raphael Mechoulam of Hebrew
University in Jerusalem gave a lecture about recent research in his laboratory
focusing on research on endogenous cannabinoid receptor ligands and on the
experimental and first positive clinical studies (Phase I and II) with the
nerve-protecting synthetic THC-derivative Dexanabinol (HU-211) which may be
useful in stroke, traumatic brain injury and damage due to nerve gas. Jörg
Fachner from the University Witten-Herdecke reflected the use of the
psychoactivity of marijuana nowadays, in psychotherapy, in music and other arts,
and in personal use, describing the psychological and spiritual dimensions of
the drug experience.
Dr. Kirsten Muller-Vahl from the
Medical School of Hannover gave an overview of the use of marijuana in movement
disorders, discussed the possible physiological and pathophysiological role of
the cannabinoid receptor system in movement and movement disorders, and gave an
overview of her research with THC in Tourette-syndrome, a serious movement
disorder. She noticed that attention increased in some patients while under THC,
an observation that was regarded as very remarkable from the audience. The
participants were also impressed with a video. It showed a patient suffering
from Tourette-syndrome, before and after 10 milligrams of oral THC, which led to
an marked improvement of symptoms. A clinical study of ten Tourette patients
will be finished in December 1998.
Dr. Franjo Grotenhermen spoke about
THC and Cannabis in medical practice, i.e., the handling of the
topic in a surgery between physician and patient, how to use Cannabis and
THC and their legal aspects. Starting with some exaggerated headlines of
articles of the last few months in Ger-man papers, he gave an overview on what
realistically could be expected from Cannabis as a benefit and as
side-effects, and which aspects in this context are controversial. The
impressions in these four days were manifold and enriching. The meetings
appreciably animated political and medical discussion about the therapeutic
potential of Cannabis in relation to perceptions of the actual national
and worldwide legal situations.
Franjo Grotenhermen
nova-Institute